Search results for "Infectious Diseases"
Inpatient oral penicillin challenge more likely in certain low-risk patients
An inpatient penicillin allergy program showed that patients were more likely to proceed from assessment to oral challenge if they had a low-risk phenotype, had an indication for beta-lactam antibiotic therapy, and were medically stable.
https://acphospitalist.acponline.org/archives/2023/03/29/inpatient-oral-penicillin-challenge-more-likely-in-certain-low-risk-patients.htm
29 Mar 2023
CDC study shows uptick in C. auris infections in recent years
Cases and transmission of Candida auris have continued to rise since the multidrug-resistant fungus was first reported in the U.S. in 2016. Reports of cases to the CDC rose by 44% in 2019 and 95% in 2021.
https://acphospitalist.acponline.org/archives/2023/03/22/cdc-study-shows-uptick-in-c-auris-infections-in-recent-years.htm
22 Mar 2023
Most asymptomatic C. difficile carriers in health care settings did not progress to infection
In a study at three U.S. hospitals and affiliated long-term care facilities, most patients who were found to be carriers of Clostridioides difficile had cleared the bacteria on subsequent testing, and only 13.4% were subsequently diagnosed with infection.
https://acphospitalist.acponline.org/archives/2023/03/22/most-asymptomatic-c-difficile-carriers-in-health-care-settings-did-not-progress-to-infection.htm
22 Mar 2023
CDC outlines treatment considerations for severe manifestations of mpox
A new report reviewed medical countermeasures and other treatment considerations for clinicians managing ocular infections, neurologic complications, myopericarditis, mucosal lesion complications, and uncontrolled viral spread in patients with mpox.
https://acphospitalist.acponline.org/archives/2023/03/15/free/cdc-outlines-treatment-considerations-for-severe-manifestations-of-mpox.htm
15 Mar 2023
Transitioning to oral therapy for infective endocarditis supported by real-world study
A retrospective study at three L.A. hospitals found similar rates of clinical success at 90 days in patients who received entirely IV therapy or were transitioned to oral antibiotics for infective endocarditis, and adverse events were less common in the latter group.
https://acphospitalist.acponline.org/archives/2023/03/15/transitioning-to-oral-therapy-for-infective-endocarditis-supported-by-real-world-study.htm
15 Mar 2023
Bundled intervention may help prevent non-ventilator-associated HAP, Swiss study finds
A prevention bundle of oral care, dysphagia screening and management, mobilization, discontinuation of inappropriate proton-pump inhibitors, and respiratory therapy was strategically implemented to try to prevent non-ventilator-associated hospital-acquired pneumonia (HAP).
https://acphospitalist.acponline.org/archives/2023/03/15/bundled-intervention-may-help-prevent-non-ventilator-associated-hap-swiss-study-finds.htm
15 Mar 2023
Nearly 10% of ED patients meeting Sepsis-3 criteria did not have true infection
Of 812 patients meeting Sepsis-3 criteria in four studied EDs, 79 (9.7%) had only possible infection and 77 (9.5%) were not infected, according to later adjudication of the records by trained nonclinician reviewers.
https://acphospitalist.acponline.org/archives/2023/03/01/nearly-10-of-ed-patients-meeting-sepsis-3-criteria-did-not-have-true-infection.htm
1 Mar 2023
Remdesivir reduced mortality in inpatients on no or regular oxygen, meta-analysis finds
The patient-level analysis of all available trials of remdesivir still did not have the power to identify any effect of the drug on mortality in COVID-19 patients receiving high-flow oxygen or mechanical ventilation.
https://acphospitalist.acponline.org/archives/2023/03/01/free/remdesivir-reduced-mortality-in-inpatients-on-no-or-regular-oxygen-meta-analysis-finds.htm
1 Mar 2023
Antimicrobial prophylaxis guidelines often not followed after elective surgery
A retrospective cohort study of 521,091 inpatient surgeries at 825 U.S. hospitals found that vancomycin was the most frequently misused agent and its use was associated with increased rates of acute kidney injury.
https://acphospitalist.acponline.org/archives/2023/02/22/antimicrobial-prophylaxis-guidelines-often-not-followed-after-elective-surgery.htm
22 Feb 2023
Stopping the cycle of C. diff
Microbiota therapies offer exciting potential to reduce the burden of recurrent Clostridioides difficile infection, experts say.
https://acphospitalist.acponline.org/archives/2023/02/08/free/stopping-the-cycle-of-c-diff.htm
8 Feb 2023